NFL Week 5 schedule: What to know about upcoming games

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The Buffalo Bills and the Philadelphia Eagles are on top of the NFL through the first four weeks of the 2025 season, defeating every team that has been on their schedule so far.

In Week 5, both teams may have their biggest tests yet.

The Bills will host the New England Patriots in a division rivalry game that could impact future playoff seeding if both Josh Allen and Drake Maye have strong seasons. Their matchup will put the exclamation point on an interesting Sunday.

The Eagles will take their Super Bowl title defense tour back to Lincoln Financial Field to take on the Denver Broncos. Denver comes into the game with a fantastic defense that completely suffocated Jake Browning and the Cincinnati Bengals. Stopping the tush push might be one of the goals for the Broncos, but the Eagles proved last week they have some tricks up their sleeve to keep defenses on their toes.

Four teams have byes this week, including the Atlanta Falcons, Chicago Bears, Green Bay Packers and Pittsburgh Steelers. Additionally, the Minnesota Vikings will become the first NFL team to play back-to-back international games with their matchup against the Cleveland Browns in London.

Read below to see the rest of the schedule.